FA Cup replays will be scrapped from the first round onwards in the 2024-25 competition.
All rounds of the Emirates FA Cup will also be played on weekends, including the fifth round which has been played in midweek for the past five seasons.
The changes come as part of a new six-year agreement between the Football Association (FA) and the Premier League.
The Premier League has also removed its mid-season break from the calendar.
Matches will start in mid-August following a consecutive three-week summer break instead of a shorter spell of rest in the winter, with the decision coming from “expert advice from medical and technical departments”.
In its current format, the FA Cup has no replays from the fifth round onwards, but the FA says the move to eliminate them from an earlier stage has been made “in light of changes to the calendar driven by the expanded Uefa competitions”.
Uefa launched the Europa Conference League in 2021 and the number of teams in the Champions League group stage will rise from 32 to 36 next season, while Fifa has announced an expanded 32-team Club World Cup for 2025.
